Description

JOB SUMMARY

At Houston Methodist, the Postdoctoral Fellow position is responsible for performing basic research duties under the supervision/direction of a Physician (Principal Investigator). This position may work in a laboratory setting or may consist of computer work that supports the department’s research mission. The Weng Lab (https://weng.hmailabs.org/) is at the forefront of studying molecular mechanisms that underpin how different RNA modifications regulate endogenous RNA immunogenicity. Our investigations delve into how the deficiencies in RNA modifications can potentially induce an immunogenic transcriptome, subsequently triggering inflammatory responses and even cellular death. Specifically, our research aims to elucidate how Adenosine-to-Inosine (A-to-I) and N6-Methyladenosine (m6A) modifications work in unison to suppress endogenous RNA immunogenicity across various RNA classes. Utilizing tools such as genetic engineering, next-generation sequencing, and biochemical approaches, we seek to uncover the checkpoints of RNA modifications in inflammation regulation. The ultimate objective of our research is to leverage these findings to shed light on other inflammatory diseases, including autoimmune diseases, Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, and other neurodegenerative disorders. We are currently seeking motivated and enthusiastic Postdoctoral Fellows with a strong background in molecular biology, cell biology, genetics, genomics, immunology, or a related field to join our team. Applicants with hands-on experience in gene editing, flow cytometry, and general molecular biology techniques are especially encouraged to apply. Our lab is deeply committed to the mentorship and long-term career success of all our members. Successful applicants will have the opportunity to acquire a broad and adaptable range of skills tailored to their specific research interests and career trajectories.  

Desirable Qualifications: A proven track record of publishing academic research papers. Proficiency in molecular biology laboratory techniques and handling mammalian cell cultures. Interest in multi-omics profiling and bioinformatics. Experience in animal handling techniques.

PRIMARY JOB RESPONSIBILITIES

Job responsibilities labeled EF capture those duties that are essential functions of the job.

PEOPLE - 20%

1. Assists the physician in maintaining the functionality and operations of the Principal Investigator’s (PI) laboratory. (EF)
2. Promotes a positive work environment and leads the team to be dynamic and a focused work unit that actively helps one other to achieve optimal department results. Collaborates with all members of the department by actively communicating and reporting data in a comprehensive manner. (EF)
3. Role models to team members effective verbal, non-verbal and written communication, which includes active listening and teaching, assisting in development of such skills. (EF)
4. Provides contributions towards improvement of department scores for employee engagement, i.e. peer-to-peer accountability. (EF)

SERVICE - 20%

1. Develops research methods and performs research activities. (EF)
2. Documents research results and writes reports of results for presentation and/or publication in professional journals and other publications. (EF)

QUALITY/SAFETY - 20%

1. Follows all safety rules while on the job. Reports accidents promptly and corrects minor safety hazards. Communicates with peers and management regarding any hazards identified in the workplace. (EF)
2. Assists with implementation and education of department-based safety initiatives, standards of practice and protocols. Develops skills of team members and continually assists with improving skills, performance and outcomes. (EF)
3. Identifies opportunities for corrective action and process improvement providing recommendations and contributes to meeting department and laboratory targets for quality and safety. (EF)

FINANCE - 20%

1. Utilizes resources effectively and efficiently, demonstrating responsible financial stewardship. Manages own time effectively and prioritizes work to achieve maximum results in a timely manner. (EF)
2. Uses resources efficiently; does not waste supplies. Self-motivated to independently manage time effectively and prioritize daily tasks. (EF)

GROWTH/INNOVATION - 20%

1. Participates in pertinent research activities and evidenced-based practice projects. Participates in departmental projects and activities. Acts as a change agent. (EF)
2. Seeks opportunities to expand learning beyond baseline competencies with a focus on continual development. Remains current on professional issues and clinical skills. Completes and updates the My Development Plan on an on-going basis. Ensures own career discussions occur with appropriate management. (EF)

This job description is not intended to be all inclusive; the employee will also perform other reasonably related business/job duties as assigned. Houston Methodist reserves the right to revise job duties and responsibilities as the need arises.

Requirements

EDUCATION REQUIREMENTS

o Postdoctoral Fellow 0, 1, 2, 3, 4 – Doctor of Medicine (MD) from an accredited medical school or Doctoral Degree (PhD) in medical field (A letter from the academic institution certifying that all student work is complete will be considered for Postdoctoral Fellow 0 only.)

EXPERIENCE REQUIREMENTS

o Postdoctoral Fellow 0– None

o Postdoctoral Fellow 1– One year of Postdoc experience

o Postdoctoral Fellow 2 – Two years’ Postdoc experience

o Postdoctoral Fellow 3 – Three years’ Postdoc experience

o Postdoctoral Fellow 4 – Four years’ Postdoc experience

Company Profile:

Houston Methodist Academic Institute was formed to rapidly and efficiently translate discoveries made in the laboratory and the clinic into new diagnostics, therapies and treatments. The Research Institute was created in 2004 to provide the infrastructure and support for these endeavors and to house the technology and resources needed to make innovative breakthroughs in important areas of human disease. A 540,000-square-foot building dedicated to research and clinical trials, the Academic Institute houses over 2,110 credentialed researchers conducting 1,387 ongoing clinical protocols.

Equal Employment Opportunity

Houston Methodist is an Equal Opportunity Employer.

Equal employment opportunity is a sound and just concept to which Houston Methodist is firmly bound. Houston Methodist will not engage in discrimination against or harassment of any person employed or seeking employment with Houston Methodist on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, status as a protected veteran or other characteristics protected by law. VEVRAA Federal Contractor – priority referral Protected Veterans requested.